Our lead indication is Alzheimer's disease, a poorly understood disease affecting a third of the 65+ age population.



Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

L1CAM isolation in a large cohort of pre-symptomatic AD. [link]


Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

L1CAM isolation description of the method. [link]


In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles

L1CAM isolation to detect diet effect on insulin resistance. [link]


Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

L1CAM isolation for accelerated motor decline with age [link]


Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models

L1CAM isolation from mice. [link]


Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

L1CAM isolation and measurement of AD pathogenic proteins in AD and FTD. [link]


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